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Year Number of Results
1996 1
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2004 33
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2006 30
2007 36
2008 39
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666 results

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Targeted pharmacologic inhibition of S-phase kinase-associated protein 2 (SKP2) mediated cell cycle regulation in lung and other RB-Related cancers: A brief review of current status and future prospects.
Elahi AH, Morales CS, Xu XL, Eliades A, Patsalis PC, Abramson DH, Jhanwar SC. Elahi AH, et al. Adv Biol Regul. 2023 May;88:100964. doi: 10.1016/j.jbior.2023.100964. Epub 2023 Mar 14. Adv Biol Regul. 2023. PMID: 37004354 Review.
SKP2 is the synthetic lethal gene in SCLC and retinoblastoma, so SKP2 can be used for targeted therapy in SCLC and retinoblastoma. ...TRbeta2 knockdown in Y79, RB177 and H209 caused SKP2 downregulation and degradation, p27 up-regulation, and S phase …
SKP2 is the synthetic lethal gene in SCLC and retinoblastoma, so SKP2 can be used for targeted therapy in SCLC and retinoblast …
Gene S-phase kinase associated protein 2 is a novel prognostic marker in human neoplasms.
Li GS, Huang T, Zhou HF. Li GS, et al. BMC Med Genomics. 2023 Jun 12;16(1):128. doi: 10.1186/s12920-023-01561-4. BMC Med Genomics. 2023. PMID: 37308972 Free PMC article.
METHODS: Based on 19,515 samples from multiple sources, for the first time, this study provided an overview of gene S-phase kinase associated protein 2 (SKP2) in pan-cancer. Differential SKP2 expression in multiple compariso …
METHODS: Based on 19,515 samples from multiple sources, for the first time, this study provided an overview of gene S-phase …
S-Phase Kinase-associated Protein-2 Rejuvenates Senescent Endothelial Progenitor Cells and Induces Angiogenesis in Vivo.
Wang HH, Lee YN, Su CH, Shu KT, Liu WT, Hsieh CL, Yeh HI, Wu YJ. Wang HH, et al. Sci Rep. 2020 Apr 20;10(1):6646. doi: 10.1038/s41598-020-63716-y. Sci Rep. 2020. PMID: 32313103 Free PMC article.
Cell cycle slowdown or arrest is a prominent feature of cellular senescence. S-phase kinase-associated protein-2 (Skp2), an F-box subunit of SCF(Skp2) ubiquitin ligase, is a key regulator of G1/S transition. ...Depletion of …
Cell cycle slowdown or arrest is a prominent feature of cellular senescence. S-phase kinase-associated protei …
A critical role of the endothelial S-phase kinase-associated protein 2/phosphatase and tensin homologue axis in angiogenesis and psoriasis.
Xie X, Cui Q, Jiang T, Zhao Z, Liu Z, Liu J, Yao Q, Wang Y, Dang E, Wang G, Xiao L, Wang N. Xie X, et al. Br J Dermatol. 2024 Jan 23;190(2):244-257. doi: 10.1093/bjd/ljad399. Br J Dermatol. 2024. PMID: 37850885
Aberrant expression of E3 ubiquitin ligase and a dysregulated protein ubiquitination system are implicated in the pathogenesis of psoriasis. OBJECTIVES: To examine the potential role of S-phase kinase-associated protein 2 (Skp2), a …
Aberrant expression of E3 ubiquitin ligase and a dysregulated protein ubiquitination system are implicated in the pathogenesis of psoriasis. …
Silencing of S-phase kinase-associated protein 2 enhances radiosensitivity of esophageal cancer cells through inhibition of PI3K/AKT signaling pathway.
Wang C, Li S, Liu J, Cheng M, Wang D, Wang Y, Lu B. Wang C, et al. Genomics. 2020 Sep;112(5):3504-3510. doi: 10.1016/j.ygeno.2020.04.029. Epub 2020 Apr 30. Genomics. 2020. PMID: 32360515 Free article.
We investigated the effect of S-phase kinase-associated protein 2 (SKP2) on radiosensitivity of esophageal cancer (EC) cells. Expression of SKP2, PI3K, AKT, Bcl-2 and Bax were assayed in EC. EC cells were transfected …
We investigated the effect of S-phase kinase-associated protein 2 (SKP2) on radiosensitivit …
Thioridazine reverses trastuzumab resistance in gastric cancer by inhibiting S-phase kinase associated protein 2-mediated aerobic glycolysis.
Yang ZY, Zhao YW, Xue JR, Guo R, Zhao Z, Liu HD, Ren ZG, Shi M. Yang ZY, et al. World J Gastroenterol. 2023 Dec 7;29(45):5974-5987. doi: 10.3748/wjg.v29.i45.5974. World J Gastroenterol. 2023. PMID: 38130998 Free PMC article.
While S-phase kinase associated protein 2 (Skp2) overexpression has been implicated in the malignant progression of GC, its role in regulating trastuzumab resistance in this context remains uncertain. ...Thioridazine demonstrated t …
While S-phase kinase associated protein 2 (Skp2) overexpression has been implicated in the …
S-phase kinase-associated protein 2 promotes cell growth and motility in osteosarcoma cells.
Ding L, Li R, Sun R, Zhou Y, Zhou Y, Han X, Cui Y, Wang W, Lv Q, Bai J. Ding L, et al. Cell Cycle. 2017 Aug 18;16(16):1547-1555. doi: 10.1080/15384101.2017.1346760. Epub 2017 Aug 3. Cell Cycle. 2017. PMID: 28771075 Free PMC article.
Skp2 (S-phase kinase-associated protein 2) plays an oncogenic role in a variety of human cancers. However, the function of Skp2 in osteosarcoma (OS) is elusive. Therefore, in the current study, we explore whether Skp2 …
Skp2 (S-phase kinase-associated protein 2) plays an oncogenic role in a variety of human ca …
Prognostic role of s-phase kinase-associated protein 2 in breast cancer: A meta-analysis.
Shi Y, Li N, Ren H, Guo X, Li Q, Ma S, Wang D. Shi Y, et al. Indian J Cancer. 2015 Dec;52 Suppl 3:E153-7. doi: 10.4103/0019-509X.186559. Indian J Cancer. 2015. PMID: 27453413 Free article.
OBJECTIVE: Emerging evidence has shown that the F-box protein S-phase kinase-associated protein 2 (Skp2) plays an important role in the pathogenesis of breast cancer (BC). ...RESULTS: In total, nine studies with 1820 BC patients we …
OBJECTIVE: Emerging evidence has shown that the F-box protein S-phase kinase-associated protein 2 …
Discovery of Novel 1,3-Diphenylpyrazine Derivatives as Potent S-Phase Kinase-Associated Protein 2 (Skp2) Inhibitors for the Treatment of Cancer.
Zhang K, Hu K, Li Q, Li M, Gao K, Yang K, Zhao B, Shi XJ, Zhang L, Liu HM. Zhang K, et al. J Med Chem. 2023 Jun 8;66(11):7221-7242. doi: 10.1021/acs.jmedchem.2c01675. Epub 2023 May 19. J Med Chem. 2023. PMID: 37204466
F-box protein S-phase kinase-associated protein 2 (Skp2) is a component of cullin-RING ligases, which is responsible for recruiting and ubiquitinating substrates and subsequently plays its proteolytic and non-proteolytic role. ...A …
F-box protein S-phase kinase-associated protein 2 (Skp2) is a component of cullin-RING liga …
S-phase kinase-associated protein-2 (Skp2) promotes nucleus pulposus cell proliferation by inhibition of p27 in attenuating intervertebral disc degeneration.
Cui ZY, Shen L, Gao XS, Dong XB, Fu HY. Cui ZY, et al. Eur Rev Med Pharmacol Sci. 2020 Mar;24(6):2802-2810. doi: 10.26355/eurrev_202003_20641. Eur Rev Med Pharmacol Sci. 2020. PMID: 32271397 Free article.
OBJECTIVE: Nucleus pulposus (NP) cell proliferation plays a key role during the process of intervertebral disc degeneration (IDD). S-phase kinase-associated protein-2 (Skp2) has been proved as an important regulator for cell growth …
OBJECTIVE: Nucleus pulposus (NP) cell proliferation plays a key role during the process of intervertebral disc degeneration (IDD). S- …
666 results